3-(3-AMino-1H-pyrazol-1-yl)propanenitrile → HCID 54298987, compound

HRID 364300Notes

Reaction equation

HRID 364300 reaction equation
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1>C(#N)C>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1

Participants

4

Reactant 2

HCID 122459333-(3-AMino-1H-pyrazol-1-yl)propanenitrileHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethane

Product 1

HCID 54298987HCID 54298987, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2,2,2-Trifluoroethylisothiocyanate (3.4 g.) was added to a solution of 3-amino-1-(2-cyanoethyl)-pyrazole (2.72 g.) in acetonitrile (10 ml.) and the solution left at room temperature for 18 hours. The mixture was was evaporated to dryness and the residue recrystallised from ethanol to give 3-[3-(2,2,2-trifluoroethyl)thioureido]-1-(2-cyanoethyl)pyrazole, m.p. 164°-165°.

Workup

  1. customThe mixture was was evaporated to dryness
  2. customthe residue recrystallised from ethanol

Sources & evidence

ORD record
ord-c9d44488bba84bd3a90c89648be8b8f7
Source dataset
uspto-grants-1986_08
Patent number
US04604465

Reaction notes

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