反应详情

A mixture of 3-[2-(2,2,2-trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole (0.32 g.), saturated ethanolic ammonia (10 ml.) and Raney nickel (0.2 g.) was stirred vigorously under an atmosphere of hydrogen at room temperature and atmospheric pressure for 3 hours. The mixture was filtered and the filtrate evaporated to dryness to give 3-[2-(2,2,2-trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole which was used without further purification.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated to dryness