3-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole → 3-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole

HRID 364302Notes

Reaction equation

HRID 364302 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][N:4]=[C:5]([NH2:16])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][C:14]#[N:15])[N:8]=1>[Ni].N>[F:18][C:2]([F:1])([F:17])[CH2:3][N:4]=[C:5]([NH2:16])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][NH2:15])[N:8]=1

Participants

4

Reactant 1

HCID 212988793-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole

Product 1

HCID 212987663-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

A mixture of 3-[2-(2,2,2-trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole (0.32 g.), saturated ethanolic ammonia (10 ml.) and Raney nickel (0.2 g.) was stirred vigorously under an atmosphere of hydrogen at room temperature and atmospheric pressure for 3 hours. The mixture was filtered and the filtrate evaporated to dryness to give 3-[2-(2,2,2-trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole which was used without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-f164c86e84d14160a79da1282e081dff
Source dataset
uspto-grants-1986_08
Patent number
US04604465

Reaction notes

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