反应详情

In 50 ml of ethanol was dissolved 3 g of cyclooctylamine. To the solution was added 11.41 g of 2-[bis-(4-benzyloxyphenyl)methyl]benzaldehyde obtained by Reference Example 8, and the mixture was heated under reflux for 2 hours. Thereafter, 1.78 g of sodium borohydride was added thereto, and the mixture was heated under reflux for 2 hours. The solvent was evaporated-under reduced pressure, and water was added to the residue. The aqueous mixture was extracted with ether, and the organic layer was separated. The aqueous layer was extracted with ether, and then the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized to afford 9.19 g of the desired product (Compound 82).

1. customobtained by Reference Example 8
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hours
4. temperaturethe mixture was heated
5. temperatureunder reflux for 2 hours
6. additionwas added to the residue
7. extractionThe aqueous mixture was extracted with ether
8. customthe organic layer was separated
9. extractionThe aqueous layer was extracted with ether
10. dry with materialdried over anhydrous magnesium sulfate
11. customThe solvent was evaporated under reduced pressure
12. customthe residue was recrystallized