HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 364455Generated: October 30, 2026
Sodium Bicarbonate → HCID 53897917, compound
https://huagongshe.com/reaction/364455
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-chloro-2-(ethoxyimino)-3-oxobutanoate | HCID 53877278 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 53897917 | HCID 53897917 | 34.8% |
Reaction Steps
A mixture of ethyl 2-ethoxyimino-3-oxo-4-chlorobutyrate (syn isomer 38.7 g.), thiourea (13.2 g.), sodium acetate (14.3 g.), methanol (95 ml.) and water (95 ml.) was stirred at 48° C. for 40 minutes. After the resultant solution was adjusted to pH 6.5 with an aqueous solution of sodium bicarbonate, the appeared precipitates were collected by filtration and washed with diisopropyl ether to give ethyl 2-(2-amino-4-thiazolyl)-2-ethoxyiminoacetate (syn isomer, 14.7 g.), mp 130° to 131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04604456 |
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| Source dataset | uspto-grants-1986_08 |
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| ORD ID | ord-329e70042fb745ca8ddc1352ad3e04eb |
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| Source note | uspto-grants-1986_08 |
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