Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acid

Participants

Role	Name	HCID	Charge
Reactant	Acetic Anhydride	HCID 7918	—
Reactant	2-(2-Amino-4-thiazolyl)-2-ethoxyiminoacetic acid	HCID 53424235	—
Solvent	Formic Acid	HCID 284	—
Product	2-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acid	HCID 54458077	87.7%

Reaction Steps

2-(2-Aminothiazol-4-yl)-2-ethoxyiminoacetic acid (syn isomer, 100 g.), formic acid (85.5 g.) and acetic anhydride (190.1 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-ethoxyiminoacetic acid (syn isomer, 99.1 g.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04604456
Source dataset	uspto-grants-1986_08
ORD ID	ord-d3b46526545c4e0ea58717bbf69f5912
Source note	uspto-grants-1986_08