HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-(2-amino-4-thiazolyl)-2-(1-methylethoxyimino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-chloro-3-oxo-2-iso-propoxyiminobutyrate | HCID 54571966 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-amino-4-thiazolyl)-2-(1-methylethoxyimino)acetate | HCID 54000557 | 60.3% |
Reaction Steps
Ethyl 4-chloro-3-oxo-2-iso-propoxyiminobutyrate (syn isomer, 41.5 g.), thiourea (13.4 g.), sodium acetate (14.4 g.), water (110 ml.) and ethanol (110 ml.) were treated in a similar manner to that of Example D-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-iso-propoxyiminoacetate (syn isomer, 27.3 g.), mp. 162° to 164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604456 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-486a4ceb92864dd6879168d7ea103a3b |
| Source note | uspto-grants-1986_08 |