Thionyl Chloride → 2-[Bis(4-acetoxyphenyl)methyl]benzoyl chloride

HRID 36448Notes

Reaction equation

HRID 36448 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28](=[O:30])[CH3:29])=[CH:23][CH:22]=2)[C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14](O)=[O:15])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].S(Cl)([Cl:33])=O>C(Cl)Cl>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28](=[O:30])[CH3:29])=[CH:23][CH:22]=2)[C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([Cl:33])=[O:15])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 199380752-[Bis(4-acetoxyphenyl)methyl]benzoic acid

Product 1

HCID 152967802-[Bis(4-acetoxyphenyl)methyl]benzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 50 ml of methylene chloride was dissolved 7 g of 2-[bis(4-acetoxyphenyl)methyl]benzoic acid obtained by Reference Example 1, and then 10 ml of thionyl chloride was added dropwise to the solution at room temperature. The reaction mixture was stirred for 2 hours, and the reaction mixture was concentrated under reduced pressure to afford 11.33 g of the desired compound as an oily matter.

Workup

  1. customobtained by Reference Example 1
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d83f8938d53c49d9bb2e0f29f30c50d5
Source dataset
uspto-grants-1995_05
Patent number
US05413997

Reaction notes

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