HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-aminothiazol-4-yl)2-n-hexyloxyiminoacetate | HCID 53940552 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid | HCID 54070599 | 91% |
Reaction Steps
Ethyl 2-(2-aminothiazol-4-yl)2-n-hexyloxyiminoacetate (syn isomer, 29.1 g.), methanol (97.2 ml.), 2N aqueous solution of sodium hydroxide (97.2 ml.) and tetrahydrofuran (50 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid (syn isomer, 24.0 g.), mp. 174° C. (dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604456 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-f63b1edca1514060ad493cebe5c694c0 |
| Source note | uspto-grants-1986_08 |