Methanol → 2-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Ethyl 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetate	HCID 54426052	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid	HCID 54540176	86.9%

Reaction Steps

Ethyl 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetate (syn isomer, 28.6 g.), 2N aqueous solution of sodium hydroxide (100.2 ml.), methanol (100 ml.) and tetrahydrofuran (100 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetic acid (syn isomer, 22.4 g.), mp 176° C. (dec.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04604456
Source dataset	uspto-grants-1986_08
ORD ID	ord-02529edff491447fafc4f46f9a9b6013
Source note	uspto-grants-1986_08