HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate | HCID 53650816 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid | HCID 53829489 | 85.3% |
Reaction Steps
Ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate (syn isomer, 30.5 g.), 1N aqueous solution of sodium hydroxide (220 ml.), methanol (110 ml.) and tetrahydrofuran (140 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)-acetic acid (syn isomer, 23.4 g.), mp 201° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604456 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-d07fd46a1efd4490a068cbc70eb811dd |
| Source note | uspto-grants-1986_08 |