Water → HCID 86740955, compound

Participants

Reaction Steps

10 g of 4'-chloro-2-(2-pyrazinyl)-acetophenone, 10 g of hydroxylamine hydrochloride and 12 g of anhydrous sodium carbonate are stirred at 60° in 100 ml of ethanol for 2 hours. The mixture is then treated with water and extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and subsequently concentrated. The residue is crystallized from acetone/n-hexane to yield 4'-chloro-2-(2-pyrazinyl)-acetophenone oxime, m.p. 134°.

Provenance & Evidence