Benzaldehyde → 6254-48-4

Participants

Reaction Steps

Glycine (60 g) and 48 g of sodium hydroxide were dissolved in 500 g of water. Then, 0.5 g of trioctylmethyl ammonium chloride was added, and with stirring at 25° to 30° C., a solution of 169.6 g of benzaldehyde in 150 g of toluene was added dropwise over the course of about 1 hour. The reaction was further carried out at 25° to 35° C. for 20 hours. After the reaction, 209 g of 35% hydrochloric acid was added dropwise at a temperature of less than 40° C. The mixture was stirred at room temperature for 1 hour. After standing, the lower aqueous layer was separated, neutralized with 45% sodium hydroxide to a pH of 6 at room temperature, stirred at 0° to 5° C. for 1 hour, filtered, washed with cold water, and dried to give 125.3 g of β-phenylserine. The purity of the product was 90.6%. The yield based on glycine was 78.3%.

Provenance & Evidence