反应详情

4-(3-Bromopropyl)-1-piperidinecarboxaldehyde (60 g, 0.256M) and NaCN (25 g) in ethanol (600 ml) was refluxed for 7 hours, Solvent was removed, added water (300-400 ml) and extracted with CH2Cl2 (4×200 ml). The extracts, dried over Na2SO4 was stripped to dryness which was purified on silica gel columns, eluted with ethylacetate-hexane (8:2 parts by volume) to yield 4-(3-cyanopropyl)-1-piperidinecarboxaldehyde (28.4 g, 61% yield).

1. customSolvent was removed
2. additionadded water (300-400 ml)
3. extractionextracted with CH2Cl2 (4×200 ml)
4. dry with materialThe extracts, dried over Na2SO4
5. customwas purified on silica gel columns
6. washeluted with ethylacetate-hexane (8:2 parts by volume)