HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 364710Generated: October 29, 2026
1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) → 4-[3-(4,5-dihydro-1H-imidazol-2-yl)propyl]piperidine
https://huagongshe.com/reaction/364710
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) | HCID 225030 | — |
| Reactant | 4-(3-Cyanopropyl)-1-piperidinecarboxaldehyde | HCID 20239759 | — |
| Reactant | HCID 178418582 | HCID 178418582 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[3-(4,5-dihydro-1H-imidazol-2-yl)propyl]piperidine | HCID 13281189 | 72.5% |
Reaction Steps
To 4-(3-cyanopropyl)-1-piperidinecarboxaldehyde (10 g, 0.055M), there was added ethylenediamine p-toluenesulfonate (30 g, 0.129M) and the mixture was heated at 200° C. for 41/2 hours. The reaction mixture was dissolved in ethanol (100 ml), basified with MeONa (0.26M), filtered and stripped to dryness. The residue was distilled at 170° C., 0.025 mmHg to give 4-[3-(4,5-dihydro-1H-imidazol-2-yl)propyl]piperidine (7.86 g, 72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04605744 |
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| Source dataset | uspto-grants-1986_08 |
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| ORD ID | ord-1f60c9de2e66477588ee22b0a41547e8 |
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| Source note | uspto-grants-1986_08 |
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