Potassium Carbonate → HCID 20207215, compound

Participants

Reaction Steps

5.3 g. of 1-(3-chlorophenyl)-1-(2-hydroxyphenyl)-propan-1-ol and 3.3 g. of monochloroacetic acid diethyl amide are dissolved in 36 ml. of n-propanol, and the reaction mixture is boiled for 4 hours, with stirring in the presence of 3 g. of anhydrous potassium carbonate. After cooling the solvent is distilled off under reduced pressure. To the residue water is added and it is extracted with ether. The ethereal solution is washed with water, a 5% aqueous sodium hydroxide solution and again with water until neutral. After drying over anhydrous magnesium sulfate, the solvent is distilled off in vacuo. The residue is crystallized from a mixture of n-hexane and ethyl acetate to yield 5.8 g. of the named compound, melting at 93°-94° C.

Provenance & Evidence