Dimethyl Sulfate → HCID 13672731, compound

Participants

Reaction Steps

Two (2) grams of 2-(pyrid-3-yl)-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran was dissolved in 50 ml of methylene chloride at room temperature. 0.24 g of sodium hydroxide, dissolved in the minimum amount of water needed to dissolve the sodium hydroxide, and 0.46 g of benzyltrimethylammonium chloride was added. Then a solution containing 0.79 g of dimethylsulfate in about 10 ml of methylene chloride was slowly added and the mixture stirred for two days at room temperature. The mixture was then washed with water, dried over magnesium sulfate and evaporatyed to a solid residue. The residue was triturated with 30% vol. ethyl acetate: 70% petroleum ether and filtered.

Provenance & Evidence