Triethyl phosphite → HCID 13712240, compound

Participants

Reaction Steps

Triethyl phosphite (50.0 g) was added to 31.0 g of 2-(4-bromomethylphenyl)-5-fluorobenzothiazole, and the mixture was reacted at 150° to 160° C. for 15 minutes under a stream of nitrogen. The reaction mixture was allowed to cool to room temperature, and 100 ml of n-hexane was added. The precipitated crystals were collected by filtration and dried to give 39.0 g of crude crystals. Recrystallization from a mixture of ethyl acetate and cyclohexane gave 30.0 g of the captioned compound as colorless needle-like crystals.

Provenance & Evidence