HCID 13714127, compound → HCID 13714128, compound

HRID 364889Notes

Reaction equation

HRID 364889 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:24])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[C].[Pd]>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:24])=[CH:17][CH:18]=1

Participants

3

Reactant 1

HCID 13714127HCID 13714127, compound

Product 1

HCID 13714128HCID 13714128, compoundYield 81.7%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Suspension of 3.25 g. (10 mmole) of N-benzyl-N'-(4-methoxyphenylcarbamoyl)piperazine and 0.10 g. of 5%-palladium-carbon was stirred under hydrogen at 60° C. for 7 hours. After the catalyst was filtered off, ethanol was evaporated under reduced pressure to give 1.92 g. of the desired product as oily substance.

Workup

  1. additionSuspension of 3.25 g
  2. filtrationAfter the catalyst was filtered off
  3. customethanol was evaporated under reduced pressure
  4. customto give 1.92 g

Sources & evidence

ORD record
ord-97032a80e918482c813f03e735b70e5a
Source dataset
uspto-grants-1986_08
Patent number
US04607034

Reaction notes

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