HCID 70040791, compound → HCID 70455662, compound

HRID 364933Notes

Reaction equation

HRID 364933 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:18]=[CH:17][C:11]([CH:12]=[CH:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1>CC(C)=O>[OH2:15].[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:18]=[CH:17][C:11]([CH:12]=[CH:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 70040791HCID 70040791, compound

Product 1

HCID 70455662HCID 70455662, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In 30 ml of 50% (V/V%) aqueous acetone 10 g of 4-(1-imidazolylmethyl)cinnamic acid hydrochloride was dissolved by heating and the solution was filtrated and then 60 ml of acetone was added to the filtrate. The mixture was allowed to stand overnight at room temperature. The resulting precipites were collected by filtration and dried at room temperature for 3 hr under reduced pressure to obtain 8.5 g of 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate. This product had the same IR-absorption spectrum and NMR spectrum as those of the product of EXAMPLE 1.

Workup

  1. temperatureby heating
  2. filtrationthe solution was filtrated
  3. addition60 ml of acetone was added to the filtrate
  4. filtrationThe resulting precipites were collected by filtration
  5. customdried at room temperature for 3 hr under reduced pressure

Sources & evidence

ORD record
ord-b7b8b30435384f9db789d582edf118ed
Source dataset
uspto-grants-1986_08
Patent number
US04607046

Reaction notes

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