Dimethylformamide dimethyl acetal → 4-(Dimethylamino)-3-[4-(4-phenyl-1-piperidinyl)phenyl]-3-buten-2-one

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Reaction Steps

A mixture of 4.0 g of 1-[4-(4-phenyl-1-piperidinyl)phenyl]-2-propanone and 16 ml of dimethylformamide dimethylacetal is stirred at room temperature overnight, followed by heating at 45°-60° C. for six hours. The solvent is evaporated and the residue triturated with two 100 ml portions of hexane. The solid is filtered and dried to give 3.5 g of orange powder, mp 93°-100° C. Upon standing overnight at 0° C., the filtrate gave an additional 0.7 g of the product, mp 103.5°-105° C. This material is used directly for the next step without further purification.

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