反应详情

16.0 g. of 2,6-dichlorobenzoylisocyanate are added in small portions to a solution of 11.66 g. of p-chloroanilino-acetonitrile in 100 ml. of dry benzene with moderate cooling. After some time a substance crystallizes out, which after about 12 hours is drawn off and washed with benzene. After drying the weight is 25.25 g, i.e. 93.7% the melting point being 185° C., with spontaneous decomposition on the Kofler heating bench. Thin-layer chromatography (solvent either ethylacetate or chloroform) shows that the substance is pure, however, if desired, it may be recrystallized from 250 ml. of benzene with a yield of 80%.

1. customAfter some time a substance crystallizes out
2. washwashed with benzene
3. customAfter drying the weight
4. custombeing 185° C., with spontaneous decomposition on the Kofler
5. temperatureheating bench
6. customit may be recrystallized from 250 ml