Potassium Hydroxide → HCID 20238660, compound

Participants

Reaction Steps

The product of step (a) (0.45 g, 0.8 mmoles) was dissolved in 95% aqueous ethanol (20 ml) by heating, and then potassium hydroxide (10.16 ml of 0.2M in 95% aqueous ethanol) was added dropwise. The solution was heated at reflux for 3 hours and then the ethanol removed in vacuo. The residue was dissolved in water (75 ml), 5% aqueous sodium hydroxide (6 ml) and chloroform (100 ml). The aqueous layer was separated and extracted several times with chloroform. The combined extracts were washed with water, dried (MgSO4) and the solvent was removed in vacuo. The residue was crystallised from 2-propanol to give the title compound (0.19 g) mp 147°-8° (dec.).

Provenance & Evidence