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HRID365004

反应详情

EQUATION

反应方程式

HRID 365004 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1
HCID3018360

N-{4-Hydroxy-5-[(6-methylpyridin-3-yl)methyl]pyrimidin-2-yl}nitramide

C11H11N5O3

结构：CN(C)Cc1ccnc(CCCCN)c1
HCID20239072

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(Cc2cnc(NCCCCc3cc(CN(C)C)ccn3)[nH]c2=O)cn1
HCID13292608

未命名化合物

收率 43.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A mixture of 4-(4-dimethylaminomethyl-2-pyridyl)butylamine (1 g) and 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone (1.26 g) in pyridine (5 ml) was refluxed for 4.5 hours. The solvent was removed in vacuo, the residue chromatographed and then crystallised from ethanol:ether (1:10) to yield 2-[4(4-dimethylaminomethyl-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone (0.86 g) m.p. 135°-137°.

WORKUP

后处理

  1. temperaturewas refluxed for 4.5 hours
  2. customThe solvent was removed in vacuo
  3. customthe residue chromatographed
  4. customcrystallised from ethanol:ether (1:10)