1-Chloro-4-(trifluoromethyl)benzene → Propenyl 4-trifluoromethylphenyl ether

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.0 kg of allyl alcohol and 6.2 kg of 4-chlorobenzotrifluoride was added over 6 hours to a stirred mixture of 6.8 kg of 85% potassium hydroxide and 17.4 g of tetraglyme at 80° C. The temperature was then raised to 100° C. for 2.5 hours, after which time the reaction mixture was cooled and distilled, and the residue was triturated with toluene and re-distilled to give 4.7 kg of propenyl 4-trifluoromethylphenyl ether.

Provenance & Evidence