L-Aspartic acid diethyl ester hydrochloride → N-(3,5-diacetamido-2,4,6-triiodobenzoyl)-L-aspartic acid diethyl ester

HRID 365033Notes

Reaction equation

HRID 365033 reaction equation
[C:1]([NH:4][C:5]1[C:6]([I:20])=[C:7]([C:11]([I:19])=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[C:13]=1[I:14])[C:8](Cl)=[O:9])(=[O:3])[CH3:2].Cl.[CH2:22]([O:24][C:25](=[O:34])[C@H:26]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[NH2:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:34])[C@H:26]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[NH:27][C:8](=[O:9])[C:7]1[C:6]([I:20])=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[C:13]([I:14])=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[C:11]=1[I:19])[CH3:23]

Participants

3

Reactant 2

HCID 12416466L-Aspartic acid diethyl ester hydrochlorideHCID 160896703,5-Diacetamido-2,4,6-triiodobenzoyl chloride

Product 1

HCID 54185974N-(3,5-diacetamido-2,4,6-triiodobenzoyl)-L-aspartic acid diethyl ester

Procedure

Following the procedure of example 13, 112 g (65%) of the product is synthesized from 140 g (0.22 Mol) 3,5-diacetamido-2,4,6-triiodobenzoyl chloride and 75 g (0.33 Mol) L-aspartic acid diethyl ester hydrochloride.

Sources & evidence

ORD record
ord-213b2634ecb543489b962c49669ff474
Source dataset
uspto-grants-1986_08
Patent number
US04607123

Reaction notes

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