2-Nitrophenol → HCID 18604142, compound

HRID 365038Notes

Reaction equation

HRID 365038 reaction equation
[C:1]([NH:4][C:5]1[C:6]([I:28])=[C:7]([C:19]([I:27])=[C:20]([NH:23][C:24](=[O:26])[CH3:25])[C:21]=1[I:22])[C:8]([NH:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])(=[O:3])[CH3:2].[N+:29]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1O)([O-:31])=[O:30].C1(N=C=NC2CCCCC2)CCCCC1>>[N+:29]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[O:17][C:16](=[O:18])[C@H:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[NH:10][C:8](=[O:9])[C:7]1[C:6]([I:28])=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[C:21]([I:22])=[C:20]([NH:23][C:24](=[O:26])[CH3:25])[C:19]=1[I:27])([O-:31])=[O:30]

Participants

4

Reactant 3

HCID 69472-NitrophenolHCID 10868DicyclohexylcarbodiimideHCID 54439452HCID 54439452, compound

Product 1

HCID 18604142HCID 18604142, compound

Procedure

Following the procedure of example 33, the product is synthesized from 14.6 g (20 mMol) N-(3,5-diacetamido-2,4,6-triiodobenzoyl)-L-leucine, 3,5 g (25 mMol) o-nitrophenol and 5 g (24 mMol) N,N'-dicyclohexylcarbodiimide. Yield: 12.5 g (73%).

Sources & evidence

ORD record
ord-9e26a9ef6c024bef9e398d014db9e0a2
Source dataset
uspto-grants-1986_08
Patent number
US04607123

Reaction notes

Loading…