Dicyclohexylcarbodiimide → HCID 13645142, compound

Participants

Reaction Steps

To 100 ml of dichloromethane solution containing 1.99 g of 2-[4-(4-cyanophenoxy)-phenoxy]-propionic acid, which was cooled with ice water, was added slowly 1,46 g of dicyclohexylcarbodiimide with stirring. After this mixture was stirred for 15 minutes, 0.76 g of 2-amino-6-methylpyridine was added thereinto with stirring. A temperature of reacting mixture was returned to room temperature with stirring. A precipitated solid was removed through filtration, and then the obtained solution was poured into 200 ml of chilled water. An organic layer was separated therefrom, and it was washed with dilute hydrochloric acid, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride in this order, from which the solvent was distilled away after drying. The residue was purified through a column-chromatography [silica gel, developed with benzene/ethyl acetate=10/1(V/V)] to give 1.53 g of the title compound having melting point of 109°-111° C.

Provenance & Evidence