Furo[2,3-b]pyridine-5,6-dicarboxylic acid → Furo[2,3-b]pryidine-5,6-Dicarboxylic anhydride

HRID 365091Notes

Reaction equation

HRID 365091 reaction equation
[O:1]1[C:5]2=[N:6][C:7]([C:13]([OH:15])=[O:14])=[C:8]([C:10]([OH:12])=O)[CH:9]=[C:4]2[CH:3]=[CH:2]1>C(OC(=O)C)(=O)C>[O:1]1[C:5]2=[N:6][C:7]3[C:13](=[O:14])[O:15][C:10](=[O:12])[C:8]=3[CH:9]=[C:4]2[CH:3]=[CH:2]1

Participants

3

Reactant 1

HCID 13752512Furo[2,3-b]pyridine-5,6-dicarboxylic acid

Product 1

HCID 13752513Furo[2,3-b]pryidine-5,6-Dicarboxylic anhydrideYield 88.4%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

Furo[2,3-b]pyridine-5,6-dicarboxylic acid (6.7 g, 0.032 mol) is heated at 60° C. for 30 minutes in acetic anhydride (150 mL). The reaction mixture is cooled to room temperature and concentrated in vacuo and the residue triturated with cyclohexane-ether (5:1), filtered off and dried to give 5.35 g furo[2,3-b]pyridine-5,6-dicarboxylic acid anhydride.

Workup

  1. concentrationconcentrated in vacuo
  2. customthe residue triturated with cyclohexane-ether (5:1)
  3. filtrationfiltered off
  4. customdried

Sources & evidence

ORD record
ord-72f63f5ed1544ad883cc9c0b0c1bd0c1
Source dataset
uspto-grants-1986_08
Patent number
US04608079

Reaction notes

Loading…