Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-4-nitropyridine 1-oxide | HCID 84433 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178526750 | HCID 178526750 | 43.8% |
Reaction Steps
3-[3-(Piperidinomethyl)phenoxy]propylamine (6.21 g), 2-chloro-4-nitropyridine-N-oxide (4.36 g) and triethylamine (6.32 g) were stirred, in ethanol (30 ml), under reflux for 31/2 hours. The reaction mixture was cooled gradually to 0° C. to yield 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]-4-nitropyridine-N-oxide (4.23 g), m.p. 90°-90.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04608380 |
|---|
| Source dataset | uspto-grants-1986_08 |
|---|
| ORD ID | ord-7abe3681ea07449e88db207accc5351e |
|---|
| Source note | uspto-grants-1986_08 |
|---|
