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2-Methylpyridine → 1-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylpyridine | HCID 7975 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 1-Bromohexane | HCID 8101 | — |
| 反応物 | 4-(Piperidin-1-yl)benzaldehyde | HCID 291354 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide | HCID 70455196 | 16.3% |
反応手順
2-Picoline (2.79 g, 0.03 mole) and 1-bromo-hexane (5.0 g, 0.03 mole) were heated in an oil bath at 130° C. for five hours. The resulting oil was cooled and dissolved in methanol (40 ml). 4-Piperidinobenzaldehyde (5.67 g, 0.03 mole) and piperidine (0.25 ml) were added and the mixture was refluxed under nitrogen for two hours. The addition of about 100 ml of ether to the cold solution gave red crystals which were collected and washed to give 1-hexyl-2-[(4-piperidino)styryl]-pyridinium bromide (2.1 g), melting point 212°-214° C. (decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04608379 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-d4ae4e84612e488d90a28cbe0a27cb90 |
| 出典メモ | uspto-grants-1986_08 |