HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 11-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 1810419 | — |
| Reactant | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 11-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate | HCID 20191685 | — |
Reaction Steps
To 50 ml dry DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g, 0.0186 mole), 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (4.0 g 0.019 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04608374 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-df8363d24d8d471fa045dddfeb28830f |
| Source note | uspto-grants-1986_08 |