HCID 20191660, compound → HCID 13689372, compound

HRID 365142Notes

Reaction equation

HRID 365142 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([CH:15]3[C:21]4=[CH:22][CH:23]=[CH:24][N:20]4[CH2:19][C:18]4[CH:25]=[CH:26][CH:27]=[CH:28][C:17]=4[O:16]3)[CH2:11][CH2:10]2)=O)=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:9]2[CH2:10][CH2:11][CH:12]([CH:15]3[C:21]4=[CH:22][CH:23]=[CH:24][N:20]4[CH2:19][C:18]4[CH:25]=[CH:26][CH:27]=[CH:28][C:17]=4[O:16]3)[CH2:13][CH2:14]2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 20191660HCID 20191660, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13689372HCID 13689372, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a cold solution of 11-[1-(4-methoxybenzoyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (13.0 g in 100 ml THF) was added 45 ml of a 1 molar lithium aluminum hydride solution in ethyl ether. This was stirred at room temperature for 2 hours.

Sources & evidence

ORD record
ord-8937e78b9d8d4eadbe62e666ecb2c69c
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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