HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 11-{1-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Reactant | 4-Hydroxy-3-methoxyphenethyl chloride | HCID 21224092 | — |
| Solvent | Butyl Acetate | HCID 31272 | — |
| Product | 11-{1-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689406 | — |
Reaction Steps
A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]-benzoxazepine (5.1 g, 0.019 mole), 4-hydroxy-3-methoxyphenethyl chloride (4.25 g, 0.023 mole) and NaHCO3 (11 g) in 110 ml n-butyl acetate was heated at reflux for 18 hours. The reaction mixture was then cooled, filtered and concentrated to an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04608374 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-a3b0754bd19445228a2e164f35fe5127 |
| Source note | uspto-grants-1986_08 |