HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 365155Erstellt: 25. Oktober 2026
Potassium Carbonate → 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
https://huagongshe.com/reaction/365155
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Edukt | 4-Trifluoromethylphenethyl methanesulfonate | HCID 54310915 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689409 | — |
Reaktionsschritte
A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.07 g, 0.019 mole), (p-trifluoromethylphenyl)ethyl methanesulfonate (6.08 g, 0.023 mole) and K2CO3 (10.7 g) in 150 ml dimethylformamide was heated at 90° C. for 7 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US04608374 |
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| Quelldatensatz | uspto-grants-1986_08 |
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| ORD ID | ord-09bb66417c534cf6a71efd1348a43b4c |
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| Quellennotiz | uspto-grants-1986_08 |
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