4-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione → 1-(4-Propoxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-ol

HRID 365176Notes

Reaction equation

HRID 365176 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH3:15])=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:16][CH2:17][CH2:18][NH:19][C:20]1[N:21]([CH3:30])[C:22](=[O:29])[N:23]([CH3:28])[C:24](=[O:27])[C:25]=1[CH3:26]>>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:1][CH:2]([OH:4])[CH2:3][NH:16][CH2:17][CH2:18][NH:19][C:20]2[N:21]([CH3:30])[C:22](=[O:29])[N:23]([CH3:28])[C:24](=[O:27])[C:25]=2[CH3:26])=[CH:7][CH:8]=1)[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 128188664-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dioneHCID 202377994-Propoxyphenyl glycidyl ether

Product 1

HCID 128188601-(4-Propoxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-olYield 32%

Procedure

This compound is obtained in a manner analogous to that described in Example 5 by reacting 4-propoxyphenyl glycidyl ether with 4-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione. It is obtained in a yield of 32% of theory in the form of colorless crystals which, after recrystallization from methanol, melt at 121°-123° C.

Workup

  1. customThis compound is obtained in a manner analogous to
  2. customIt is obtained in a yield of 32% of theory in the form of colorless crystals which
  3. customafter recrystallization from methanol
  4. custommelt at 121°-123° C.

Sources & evidence

ORD record
ord-b39c62ff37944f2faa917b3564c82d6a
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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