((p-(Benzyloxy)phenoxy)methyl)oxirane → 1-(4-Benzyloxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-ol

HRID 365180Notes

Reaction equation

HRID 365180 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:20][CH2:21][CH2:22][NH:23][C:24]1[N:25]([CH3:34])[C:26](=[O:33])[N:27]([CH3:32])[C:28](=[O:31])[C:29]=1[CH3:30]>>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:1][CH:2]([OH:4])[CH2:3][NH:20][CH2:21][CH2:22][NH:23][C:24]2[N:25]([CH3:34])[C:26](=[O:33])[N:27]([CH3:32])[C:28](=[O:31])[C:29]=2[CH3:30])=[CH:7][CH:8]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 119882((p-(Benzyloxy)phenoxy)methyl)oxiraneHCID 128188664-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione

Product 1

HCID 202378471-(4-Benzyloxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-olYield 30%

Procedure

Yield 30% of theory; colorless oil from 4-benzyloxyphenyl glycidyl ether and 4-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione.

Sources & evidence

ORD record
ord-f7dc44ad511941279600facfd13e9c2c
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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