2-((3,4-Bis(phenylmethoxy)phenoxy)methyl)oxirane → 1-(3,4-Dibenzyloxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-ol

HRID 365181Notes

Reaction equation

HRID 365181 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:28][CH2:29][CH2:30][NH:31][C:32]1[N:33]([CH3:42])[C:34](=[O:41])[N:35]([CH3:40])[C:36](=[O:39])[C:37]=1[CH3:38]>>[CH2:21]([O:20][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=1[O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[O:5][CH2:1][CH:2]([OH:4])[CH2:3][NH:28][CH2:29][CH2:30][NH:31][C:32]1[N:33]([CH3:42])[C:34](=[O:41])[N:35]([CH3:40])[C:36](=[O:39])[C:37]=1[CH3:38])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 5610582-((3,4-Bis(phenylmethoxy)phenoxy)methyl)oxiraneHCID 128188664-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione

Product 1

HCID 202378681-(3,4-Dibenzyloxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-olYield 32%

Procedure

Yield 32% of theory; colorless oil from 3,4-dibenzyloxyphenyl glycidyl ether and 4-(2-aminoethylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione.

Sources & evidence

ORD record
ord-bceee29b373240f99e978cceed1f8b91
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

Loading…