Ethylenediamine sulfite → 5-Methyl-4-(2-aminoethylamino)-indazole

HRID 365211Notes

Reaction equation

HRID 365211 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.S(O)(O)=O.[CH2:16](N)[CH2:17][NH2:18]>C(O)CO.O>[CH3:11][C:10]1[C:2]([NH:1][CH2:16][CH2:17][NH2:18])=[C:3]2[C:7](=[CH:8][CH:9]=1)[NH:6][N:5]=[CH:4]2

Participants

4

Reactant 2

HCID 18987913Ethylenediamine sulfiteHCID 193544325-Methyl-1H-indazol-4-amine

Product 1

HCID 202378485-Methyl-4-(2-aminoethylamino)-indazole

Reagents, catalysts & solvents 1

HCID 20437942Ethylene glycol waterSolvent

Procedure

m.p. 153°-155° C., recrystallized from water (yield 31% of theory) by reacting 4-amino-5-methylindazole with an excess of ethylenediamine sulphite in ethylene glycol-water (1:1 v/v) for 24 hours at 110° C.

Workup

  1. customfor 24 hours
  2. customat 110° C.

Sources & evidence

ORD record
ord-a6d89711a06f4bafb4361ec3f1504e4e
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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