p-Toluenesulfonic acid → HCID 54043420, compound

Participants

Reaction Steps

12.4 Parts of 2-methylhydroquinone, 14.2 parts of methyl 5-methylhex-5-enoate, and 0.5 parts of p-toluene sulphonic acid are heated on a steam bath for 24 hours. The cooled reaction mixture is treated with ether, washed firstly with a 10% aqueous solution of sodium hydroxide, and then with water until the aqueous phase is neutral. The ethereal layer is separated and evaporated to give a viscous oil which after short-path distillion at 0.13 mb gives methyl 5-(2',5'-dihydroxy-4'-methyl-phenyl)-5-methyl-hexenoate with the following percentage composition by weight.

Provenance & Evidence