Hydrochloric Acid → HCID 178479217, compound

Participants

Reaction Steps

A mixture of 9.5 g (0.016 mol) of 5-[(3-aminopropyl)amino]-2-[2-(2-hydroxyethyl)amino]ethyl]-7,10-bis(phenylmethoxy)anthra[1,9-cd[pyrazol-6(2H)-one (3) in 300 ml of acetic acid was hydrogenated over 1.7 g of 20% palladium hydroxide on carbon at atmospheric pressure and at room temperature for two hours, filtered through celite, and concentrated under vacuum. The residue was dissolved in boiling methanol. The hot solution was treated with an excess (about 0.05 mol) of hydrogen chloride in 2-propanol, and chilled overnight. The red-orange precipitate was collected, washed with 2-propanol, dried at 65° C. under vacuum for 48 hours, and allowed to equilibrate in the air overnight to afford 6.4 g (82%) of 4, containing 0.6 mole of water, mp 267°-272° C. (dec) with prior sintering.

Provenance & Evidence