HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyphenyl)piperazine → 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | Acrylonitrile | HCID 7855 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile | HCID 1822604 | 91.7% |
Reaction Steps
A solution of acrylonitrile (1.06 g, 20 mmol) in ethanol (50 ml) was added to a stirred solution of 2-methoxyphenylpiperazine (3.84 g, 20 mmol) in ethanol (100 ml). After 18 h, the solvent was evaporated in vacuo to give the product (4.5 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127357 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-22fea30183c04db69593e05118e5f118 |
| Source note | uspto-grants-2000_10 |