3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile → 1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine

Participants

Reaction Steps

A solution of the product of Example 26 (4.4 g, 18 mmol) in concentrated ethanolic ammonia solution (150 ml) was hydrogenated over 5% rhodium on alumina powder (0.6 g) at 50 p.s.i. (about 3.4×105Pa) for 50 h to give the product (3.9 g) as a brown oil.

Provenance & Evidence