反应详情

The product of Example 27 (3.9 g, 16 mmol) and 2-chloropyridine (1.82 g, 16 mmol) were heated at 160° C. in a sealed vessel for 6 h. After cooling, the residue was taken up into CH2Cl2 (50 ml) washed with aqueous NaOH (3×50 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)] to give the product (0.7 g) as a brown oil.

1. temperatureAfter cooling
2. washwashed with aqueous NaOH (3×50 ml)
3. dry with materialdried (MgSO4)
4. customevaporated in vacuo
5. customThe residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)]