HCID 23291098, compound → 1-(2-Quinolylcarbonyl)piperazine hydrochloride

HRID 365304Notes

Reaction equation

HRID 365304 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>[Pd].O>[ClH:1].[N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:25]=[CH:26][C:17]=1[C:15]([N:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)=[O:16]

Participants

4

Reactant 1

HCID 23291098HCID 23291098, compound

Product 1

HCID 232910781-(2-Quinolylcarbonyl)piperazine hydrochlorideYield 77.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

After a mixture consisting of 1-benzyl-4-(2-quinolylcarbonyl)piperazine hydrochloride (18.81 g, 51.1 mmol), 10% palladium-charcoal catalyst (3.00 g) and water (150 ml) was stirred for 3 hours at a bath temperature of 70° C. under a hydrogen gas stream, the catalyst was removed and the solvent was then distilled off. The residue was crystallized from ethanol, whereby 11.03 g of the title compound were obtained as colorless prisms (yield: 77.7%).

Workup

  1. customthe catalyst was removed
  2. distillationthe solvent was then distilled off
  3. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-94a5bcb140704e62b49b9b1de008377c
Source dataset
uspto-grants-2000_10
Patent number
US06127360

Reaction notes

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