Sodium Hydroxide → Piperazin-1-yl(quinolin-2-yl)methanone

HRID 365305Notes

Reaction equation

HRID 365305 reaction equation
Cl.[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)=[O:13].[OH-].[Na+]>O>[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)=[O:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 232910781-(2-Quinolylcarbonyl)piperazine hydrochloride

Product 1

HCID 4494363Piperazin-1-yl(quinolin-2-yl)methanoneYield 79.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(2-Quinolylcarbonyl)piperazine hydrochloride (6.18 g, 22.2 mmol) was dissolved in water. The thus-obtained solution was rendered basic with a concentrated aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform, and the extract was washed with an aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4.236 g of the title compound were obtained as a colorless oil (yield: 79.1%).

Workup

  1. extractionThe resulting mixture was extracted with chloroform
  2. washthe extract was washed with an aqueous solution of sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-c7680a733836474fb497593d405e548d
Source dataset
uspto-grants-2000_10
Patent number
US06127360

Reaction notes

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