反应详情

A hydrogen chloride ether saturated solution was added to a solution of 0.4 g (1.0 mmol) of (R)-(+)-5,11-dihydro-5-[1-(4-cyanophenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e] [1,4]oxazepine in 2 ml of dichloromethane, and the mixture was stirred for 5 minutes. Then, the solvent was distilled off under reduced pressure. The resulting residue was recrystallized from a mixed solvent of dichloromethane and diethyl ether to give 0.35 g (78%) of (R)-(+)-5,11-dihydro-5-[1-(4-cyanophenethyl)-2-pyrrolidinyl methyl]dibenzo[b,e][1,4]oxazepine hydrochloride as a colorless prism crystal in a yield of 78%.

1. distillationThen, the solvent was distilled off under reduced pressure
2. customThe resulting residue was recrystallized from a mixed solvent of dichloromethane and diethyl ether