HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,11-Dihydrodibenzo[b,e][1,4]oxazepine → (+)-5,11-dihydro-5-[[(2R, 4R)-4-(methoxymethoxy)-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]dibenzo[b,e][1,4]oxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,11-Dihydrodibenzo[b,e][1,4]oxazepine | HCID 11084798 | — |
| Reactant | (3S,5R)-(+)-3-chloro-5-(methoxymethoxy)-1-(4-methoxyphenethyl)piperidine | HCID 15481952 | — |
| Product | (+)-5,11-dihydro-5-[[(2R, 4R)-4-(methoxymethoxy)-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]dibenzo[b,e][1,4]oxazepine | HCID 15481938 | — |
Reaction Steps
(3S,5R)-(+)-3-chloro-5-(methoxymethoxy)-1-(4-methoxyphenethyl)piperidine was coupled with 5,11-dihydrodibenzo[b,e][1,4]oxazepine as described in Example 1 to give (+)-5,11-dihydro-5-[[(2R,4R)-4-(methoxymethoxy)-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]dibenzo[b,e][1,4]oxazepine in 4.30 g (72.6%) yield as pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127361 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-153fd8efd25f4a52bba6db54503188c8 |
| Source note | uspto-grants-2000_10 |