Trifluoroacetic acid → HCID 57018698, compound

Participants

Reaction Steps

A solution of 200 mg of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)-10-methoxymethyl-oxazolo-[4,5-g]-β-carboline-9-carboxylic acid isopropyl ester in 20 ml of methylene chloride is mixed drop by drop at room temperature with 1 ml of trifluoroacetic acid, and it is stirred at room temperature under protective gas for another 4 hours. The reaction solution is neutralized with the equimolar amount of sodium bicarbonate solution. The precipitated solid product is suctioned off and washed with methylene chloride. After the drying in a vacuum at 50° C., 112 mg of 2-(1,2-dihydroxyethyl)-10-methoxymethyl-oxazolo-[4,5-g]-β-carboline-9-carboxylic acid isopropyl ester with a melting point of 168° C. (decomposition) is obtained.

Provenance & Evidence