Potassium Carbonate → HCID 57168868, compound

Participants

Reaction Steps

297 mg of 6-amino-4-ethyl-β-carboline-3-carboxylic acid isopropyl ester is dissolved in 5 ml of acetic acid, mixed with 152 mg of ammonium thiocyanate and stirred for 1 hour at room temperature. Then, the reaction solution is cooled to 10° C. and mixed drop by drop with 0.05 ml of acetic bromine solution (0.5 ml of BR2 in 9.5 ml of acetic acid). It is stirred for 1 more hour at 10° C. and then heated to room temperature. The reaction mixture is taken up in ethyl acetate/water and neutralized with 10% K2CO3 solution. The organic phase is separated, dried and evaporated to dryness. The residue is triturated with ether. 214 mg of the title compound with a melting point of 160° C. (decomposition) is obtained.

Provenance & Evidence