Acetic Anhydride → HCID 57313024, compound

HRID 365343Notes

Reaction equation

HRID 365343 reaction equation
[CH:1]([O:4][C:5]([C:7]1[N:8]=[CH:9][C:10]2[NH:11][C:12]3[C:17]([C:18]=2[C:19]=1[CH2:20][CH3:21])=[C:16]1[N:22]=[C:23]([NH2:25])[S:24][C:15]1=[CH:14][CH:13]=3)=[O:6])([CH3:3])[CH3:2].[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[CH:1]([O:4][C:5]([C:7]1[N:8]=[CH:9][C:10]2[NH:11][C:12]3[C:17]([C:18]=2[C:19]=1[CH2:20][CH3:21])=[C:16]1[N:22]=[C:23]([NH:25][C:26](=[O:28])[CH3:27])[S:24][C:15]1=[CH:14][CH:13]=3)=[O:6])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 57168868HCID 57168868, compound

Product 1

HCID 57313024HCID 57313024, compound

Procedure

100 mg of 2-amino-10-ethyl-thiazolo[4,5-g]-β-carboline-9-carboxylic acid isopropyl ester is suspended in 10 ml of acetic anhydride and heated for 15 minutes to 80° C. After cooling, the settled precipitate is filtered off and recrystallized from ethyl acetate. 51 mg of 2-acetamido-10-ethyl-thiazolo[4,5-g]-β-carboline-9-carboxylic acid isopropyl ester with a melting point of 208-210° C. is obtained.

Workup

  1. temperatureheated for 15 minutes to 80° C
  2. temperatureAfter cooling
  3. filtrationthe settled precipitate is filtered off
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-2ca54b1965ad4a5eb409bf219e1f3b83
Source dataset
uspto-grants-2000_10
Patent number
US06127368

Reaction notes

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